Sample: Urine
 
Description
Mosaic Dx (formerly Great Plains) organic acid test includes 76 urinary metabolites that provide a comprehensive snapshot of a patient’s overall health as the initial screening test and is useful for discovering underlying causes for chronic illness.

Includes biomarkers for:
• Intestinal Microbial Overgrowth
• Oxalate Metabolites
• Glycolytic Cycle Metabolites
• Mitochondrial Markers (Kreb Cycle)
• Neurotransmitter Metabolites
• Folate Metabolism
• Ketone and Fatty Acid Oxidation
• Nutritional Markers
• Indicators of Detoxification
• Amino Acid Metabolites

Organic acids are chemical compounds excreted in the urine that are products of metabolism. Metabolism is the sum of chemical reactions in living beings by which the body builds new molecules and breaks down molecules to eliminate waste products and produce energy.

Organic acids are most commonly analysed in urine because they are not extensively reabsorbed in the kidney tubules after glomerular filtration. Thus, organic acids in urine are often present at 100 times their concentration in the blood serum and thus are more readily detected in urine. This is why organic acids are rarely tested in blood or serum.
 
Methodology
Organic acids are measured by a combination of gas or liquid chromatography linked with mass spectrometry
 
When should I use
The Mosaic Diagnostics (GPL) Organic Acids Test (OAT) assess 10 key areas and includes 76 organic acids to provide a comprehensive metabolic snapshot of a patient’s overall health. Organic Acids Test is an essential profile for anyone seeking additional information related to underlying gut derived bacterial and fungal toxins, as well as evaluating for less known metabolic imbalances such as mitochondrial function. It is not a test limited to just a few conditions, but instead can be done on anyone dealing with a complicated and chronic health problem.

• GI conditions – IBS, Dysbiosis/Yeast
• Chronic Fatigue/ Fibromyalgia
• Autism/AD(H) D/ Asperger Syndrome
• Mental health
• Low energy
• Depression/ Stress/Anxiety
• Eating disorders
• Cognitive decline
• Nutrient deficiencies
• Headaches/Migraines
• Joint/muscle pain
• Brain Fog
• Skin issues
 
Analytes
2-Hydroxybutyric
2-Hydroxyhippuric
2-Hydroxyisocaproic
2-Hydroxyisovaleric
2-Hydroxyphenylacetic
2-Oxo-4-methiolbutyric
2-Oxoglutaric
2-Oxoisocaproic
2-Oxoisovaleric
3-Hydroxy-3-methylglutaric (CoQ10)
3-Hydroxybutyric
3-Hydroxyglutaric
3-Indoleacetic
3-Methyl-2-oxovaleric
3-Methylglutaconic
3-Methylglutaric
3-Oxoglutaric
4-Cresol (C. di­fficile)
4-Hydroxybenzoic
4-Hydroxybutyric
4-Hydroxyhippuric
4-Hydroxyphenyllactic
5-Hydroxyindolacetate (5HIAA)
5-Hydroxymethyl-2-furoic
Acetate
Acetoacetic
Aconitic
Adipic
Arabinose
Ascorbic (Vitamin C)
Carboxycitric
Citramalic
Citric
Creatinine
DHPPA (beneficial bacteria)
Dihydroxyphenylacetic (DOPAC)
Ethylmalonic
Fumaric
Furan-2
Furancarbonylglycine
Glutaric (Vitamin B2 (Riboflavin))
Glutathione
Glyceric
Glycolic
Hippuric
Homogentisic
Homovanillate (HVA)
HPHPA (Clostridia marker)
HVA/DOPAC Ratio
HVA/VMA Ratio
Kynurenic
Lactic
Malic
Malonic
Mandelic
Methylcitric (Biotin)
Methylmalonic Acid (MMA)
Methylsuccinic
N-Acetylaspartic
N-Acetylcysteine (Glutathione precursor and chelating agent)
Orotic
Oxalic
Pantothenic (Vitamin B5)
Phenyllactic
Phenylpyruvic
Phosphoric
Pyridoxic (Vitamin B6)
Pyroglutamic
Pyruvic
Quinolinic
Sebacic
Suberic
Succinic
Tartaric
Thymine
Tricarballylic
Uracil
Vanilmandelate (VMA)
Vitamin B2
Vitamin B6
Vitamin C